- Sensitive Materials Laboratory Clean Room -
- Storage Module 1 -
STS-221 delivered two modules to the International Orbiter Space Station, the Clean Room for the Sensitive Materials Laboratory, and the first of three Storage Modules. The Clean Room acts as a preparation room for astronauts working in the Sensitive Materials Laboratory, which will be launched on the next shuttle mission. The second module that was brought up was a Storage Module, designed to house extra supplies and materials.
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| Shuttle Endeavour on the pad | STS-221 lifting off | Endeavour clear of the tower | SRB separation |
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| External tank separation | STS-221 on orbit | Endeavour making a Station-Keeping burn | Endeavour preparing to dock |
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| Moments before docking | Endeavour docked to the IOSS | The SML Clean Room grappled with the Station Arm | The Sensitive Materials Laboratory Clean Room installed to Node 2 |
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| Storage Module 1 grappled with the shuttle arm | Storage Module 1 being handed over to the Station Arm | Storage Module 1 installed on Soyuz/Progress Docking Module 2 | View of the IOSS as STS-221 departs |
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| View of the interior of the shuttle prepares for de-orbit | Endeavour buttoned up and ready for reentry | Endeavour above Cape Canaveral | Endeavour turning final |
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| Landing gear lowered | Wheels down | Wheels stop | The IOSS at the end of the mission |